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Related Experiment Video

Updated: Jul 19, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders

Published on: April 28, 2023

Copper deficiency myelopathy (human swayback).

¹Department of Neurology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA. kumar.neeraj@mayo.edu

Mayo Clinic Proceedings

|October 14, 2006

Summary

Copper deficiency can cause anemia, neutropenia, and neurological issues like myelopathy. Prompt copper supplementation can reverse these hematologic problems and potentially halt neurological decline.

Area of Science:

Neurology
Hematology
Nutritional Science

Background:

Copper deficiency is known for hematologic issues like anemia and neutropenia.
Neurological manifestations, particularly myelopathy, are increasingly recognized in acquired copper deficiency.

Observation:

Acquired copper deficiency can stem from gastric surgery, excess zinc, or malabsorption, with causes often unidentified.
Hyperzincemia may occur without external zinc intake.
Clinical and imaging findings resemble vitamin B12 deficiency-related subacute combined degeneration.

Findings:

Neurological symptoms, including spastic gait and sensory ataxia, can manifest without hematologic abnormalities.
Copper and vitamin B12 deficiencies can coexist.
Copper supplementation effectively resolves anemia and neutropenia and may prevent neurological worsening.

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Published on: September 7, 2019

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Last Updated: Jul 19, 2026

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Published on: April 28, 2023

A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay

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Published on: September 7, 2019

Implications:

Early diagnosis and copper supplementation are crucial for managing copper deficiency myelopathy.
Neurological improvement, especially sensory symptoms, can occur with treatment.
Understanding the diverse manifestations of copper deficiency is vital for clinical practice.