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Updated: Jul 19, 2026

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
Published on: February 12, 2015
[The relationship between smoking behavior in young people and CYP2A6 gene polymorphisms, between them and
Chikako Waga1, Kazuhiko Iwahashi
1Department of Neurophysiology, Graduate School of Environmental Health, Azabu University, 1-17-71 Huchinobe, Sagamihara, Kanagawa 229-8501, Japan.
Abstract:
We performed a survey on nicotine dependence among young students. We examined the CYP2A6 gene polymorphism using PCR-RFLP. We examined the personality traits using NEO-FFI. Samples were taken from young students of which 87 were smokers and 142 were non-smokers and we tried to clarify the relationship between the nicotine metabolizing ability (CYP2A6), personality, and smoking behavior. As a result, the frequency of the CYP2A6*4C gene was significantly higher among non-smokers than smokers, and the Openness score by NEO-FFI was higher among smokers than non-smokers. We concluded that the CYP2A6*4C gene and the Openness personality trait may be a cause of smoking among the young smokers. Therefore, there is a possibility that smoking behavior in youths may be affected not only by the CYP2A6 gene but also by the Openness personality trait.
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