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Nodular pulmonary amyloidosis.

Toshiteru Tokunaga¹, Shin-ichi Takeda, Noriyoshi Sawabata

¹Department of General Thoracic Surgery, Toneyama National Hospital, Toyonaka, Osaka, Japan. tokunaga@surg1.med.osaka-u.ac.jp

The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai Zasshi

|October 14, 2006

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Pulmonary amyloidosis, a rare condition, was diagnosed in a woman presenting with lung nodules. Diagnosis involved surgical resection and Congo red staining, confirming amyloid deposits.

Area of Science:

Pulmonary Medicine
Pathology
Rheumatology

Background:

Rheumatoid arthritis is an autoimmune disease that can affect multiple organs.
Pulmonary nodules can be indicative of various conditions, including inflammatory and neoplastic diseases.

Observation:

A 72-year-old woman with suspected rheumatoid arthritis presented with multiple bilateral pulmonary nodules.
Surgical resection of a pulmonary nodule was performed using video-assisted thoracic surgery for diagnosis.

Findings:

Microscopic examination revealed amorphous eosinophilic acellular substances surrounded by inflammatory infiltrates.
Congo red staining confirmed the presence of amyloid deposits, establishing the diagnosis of pulmonary amyloidosis.

Implications:

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This case highlights the importance of considering pulmonary amyloidosis in patients with unexplained pulmonary nodules, especially those with autoimmune conditions.
The diagnostic process, including surgical biopsy and histopathological staining, is crucial for accurate diagnosis and management.
Understanding the clinical features and diagnostic challenges of pulmonary amyloidosis can aid clinicians in timely diagnosis and patient care.