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[10 years plasma exchange with the IBM (Cobe) 2997]
H R Franz1, M Hohl-Taheri, B Kraatz
1Abtlg. f. Transfusionsmedizin u. Transplantationsimmunologie, Universität Hamburg.
Beitrage Zur Infusionstherapie = Contributions to Infusion Therapy
|January 1, 1990
Summary
Therapeutic plasma exchange (TPE) effectively supported patients with various conditions, including hyperviscosity syndrome and myasthenia gravis. However, TPE showed limited success in treating acute liver failure.
Area of Science:
- Internal Medicine
- Neurology
- Hematology
Context:
- Therapeutic plasma exchange (TPE) is a medical procedure involving the removal of plasma from the body.
- This study retrospectively analyzed TPE treatments administered between 1979 and 1989.
- The study included fifty patients with eighteen different diagnoses.
Purpose:
- To evaluate the efficacy and safety of non-selective therapeutic plasma exchanges (TPE).
- To assess TPE's effectiveness across a range of medical conditions.
- To identify potential complications and areas for improvement in TPE procedures.
Summary:
- A total of 385 TPE treatments were performed, with neurological diseases initially predominating.
- Replacement fluids included albumin, fresh-frozen plasma, and saline, with exchange volumes adjusted over time.
- Side effects occurred in 11% of treatments, and technical errors in 3%.
Impact:
- TPE demonstrated effectiveness as supportive therapy for hyperviscosity syndrome, myasthenia gravis, thrombotic thrombocytopenic purpura (TTP), hypercholesterolemia, Guillain-Barré Syndrome, and sickle-cell anemia.
- The procedure showed no convincing success in treating acute liver failure.
- Findings inform the application of TPE in managing specific hematological and neurological disorders.