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Molecular basis of inherited renal lithiasis
R P Holmes1, D G Assimos, H O Goodman
1Department of Urology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
Abstract:
Idiopathic calcium oxalate stone formation results from an interaction between genetic and environmental factors. Clearly identifiable risk factors for the disease that have a significant genetic influence are the excretions of calcium, oxalate and citrate. Candidate genes that may be responsible for these effects have been proposed. With the large-scale sequencing of the human genome and the identification of genetic polymorphisms, it is only a matter of time before these genes and the sequence differences within them that are associated with susceptibility to the disease are conclusively identified.
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