Molecular biology and immunology for clinicians 15: Antigen presenting cells--class I

Class I-bearing antigen presenting cells (APCs) monitor intracellular proteins which are cellular proteins made on a routine basis, endogenous proteins made by stressed cells, proteins made by infected or transformed cells, or proteins made by intracellular pathogens, e.g., viruses, chlamydiae, mycoplasma, Listeria, and some Enterobacteriaceae. The mechanisms by which peptides interact with and are expressed by class I complexes on the surface of APCs is described and contrasted with the circumstances of class II antigen presentation.