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Updated: Jul 19, 2026

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
Published on: August 13, 2013
NFAT transcription factors in control of peripheral T cell tolerance
Edgar Serfling1, Stefan Klein-Hessling, Alois Palmetshofer
1Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany. serfling.e@mail.uni-wuerzburg.de
Abstract:
The Ca++-regulated calcineurin/NFAT cascade is one of the crucial signalling pathways that controls adaptive immunity. However, a number of novel experimental data suggest that, in addition to their role in T cell activation, NFATc transcription factors play also a decisive role in the generation of peripheral tolerance against self-antigens. This function of NFATc factors is mediated by controlling activation-induced cell death and clonal anergy of T helper cells and the activity of regulatory T cells. The multi-functional role of NFATc proteins characterize these transcription factors as key regulators of immunological tolerance and, if dysregulated, of development of autoimmune diseases.
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