Related Experiment Video

Updated: Jul 19, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
08:31

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia

Published on: October 17, 2025

Induction of apoptosis in lymphoid and myeloid leukemia

Aaron D Schimmer1

  • 1Princess Margaret Hospital, Room 9-516, 610 University Avenue, Toronto, ON, M5G 2M9, Canada. aaron.schimmer@utoronto.ca

Current Oncology Reports
|October 17, 2006
PubMed

Insights

Novel drugs targeting apoptosis pathways are being developed to combat chemoresistance in acute leukemia. These compounds aim to restore programmed cell death, improving patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Apoptosis pathway defects are linked to acute leukemia chemoresistance and poor prognosis.
  • Targeting apoptosis is a key strategy to overcome treatment resistance.

Purpose of the Study:

  • To review novel compounds targeting caspase activation pathways for acute leukemia treatment.
  • To highlight therapeutic strategies addressing apoptosis defects in acute leukemia.

Main Methods:

  • Literature review of compounds targeting mitochondrial, death receptor, and convergence apoptosis pathways.
  • Analysis of drug development for acute leukemia treatment focusing on apoptosis modulation.

Main Results:

  • Several novel compounds targeting key apoptosis proteins are under development.
  • These agents aim to restore apoptotic function in leukemia cells.

Conclusions:

  • Targeting apoptosis pathways offers a promising therapeutic avenue for acute leukemia.
  • Further development of these compounds could improve treatment efficacy and patient survival.

More Related Videos

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells09:57

Real Time Detection of In Vitro Tumor Cell Apoptosis Induced by CD8+ T Cells to Study Immune Suppressive Functions of Tumor-infiltrating Myeloid Cells

Published on: January 29, 2019

Related Concept Videos

The Intrinsic Apoptotic Pathway01:31

The Intrinsic Apoptotic Pathway

Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...