Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Amebiasis

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...

Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

Giardiasis

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...

Inflammatory Bowel Disease III: Crohn's Disease

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...

Inflammatory Bowel Disease II: Ulcerative Colitis

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Peritoneal deposits with carbon pigmentation associated with endoscopic submucosal tattooing of a rectal cancer.

Endoscopy·2010

Same author

A proof of concept study establishing Necator americanus in Crohn's patients and reservoir donors.

Gut·2005

Same author

Colorectal cancer after open-access colonoscopy: a community and case survey.

The Medical journal of Australia·1999

Same author

Human enteric infection with Ancylostoma caninum: hookworms reappraised in the light of a "new" zoonosis.

Acta tropica·1996

Same author

Immunoglobulin G subclass antibodies against excretory/secretory antigens of Ancylostoma caninum in human enteric infections.

The American journal of tropical medicine and hygiene·1996

Same author

A distinctive aphthous ileitis linked to Ancylostoma caninum.

Journal of gastroenterology and hepatology·1996

Search research articles

Related Experiment Video

Updated: Jul 19, 2026

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

Published on: May 24, 2011

Hookworm-provoked IgE-mediated Pathology: Capricious Damage or Remarkable Strategy?

Parasitology Today (Personal Ed.)

|October 17, 2006

Summary

The canine hookworm Ancylostoma caninum is limited in human guts by an immune response to its secretions. This contrasts with human-adapted hookworms, which may suppress immunity, offering insights into allergy drug development.

More Related Videos

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

Published on: March 3, 2023

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Published on: April 6, 2015

Related Experiment Videos

Last Updated: Jul 19, 2026

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

Trichuris muris Infection: A Model of Type 2 Immunity and Inflammation in the Gut

Published on: May 24, 2011

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

A Strategy for the Study of IL-9-Producing Lymphoid Cells in the Nippostrongylus brasiliensis Infection Model

Published on: March 3, 2023

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Published on: April 6, 2015

Area of Science:

Immunology
Parasitology
Allergy Research

Background:

The canine hookworm Ancylostoma caninum can infect humans but is often cleared.
Human-adapted hookworm species do not typically elicit a strong immune response.
Hookworm secretions are implicated in modulating host immune responses.

Purpose of the Study:

To discuss the hypothesis that IgE-mediated inflammation limits Ancylostoma caninum in humans.
To explore how hookworm secretions might modulate immune responses in adapted species.
To consider the implications for developing anti-allergy drugs.

Main Methods:

Review of existing literature on hookworm immunology and host-parasite interactions.
Discussion of the role of IgE-mediated responses in Ancylostoma caninum infections.
Analysis of proposed mechanisms for immune evasion by anthropophilic hookworms.

Main Results:

An effective IgE-mediated inflammatory response appears to curtail Ancylostoma caninum in the human gut.
This immune response damages the host, hindering parasite feeding.
Immunity does not develop against anthropophilic hookworm species, likely due to immune modulation by their secretions.

Conclusions:

Host immune responses, particularly IgE-mediated inflammation, play a crucial role in limiting non-adapted parasitic infections.
Hookworm secretions may be key factors in immune evasion by adapted species.
Understanding these mechanisms could lead to novel therapeutic strategies for allergy suppression.