Related Experiment Video
Updated: Jul 19, 2026
05:39
Immunization of Adult Zebrafish for the Preclinical Screening of DNA-based Vaccines
Published on: October 30, 2018
Progress in development of liver fluke vaccines
1Department of Biochemistry and Molecular Biology, Monash University, Monash Australia.
Parasitology Today (Personal Ed.)
|October 17, 2006
Summary
Vaccines using Fasciola antigens can protect ruminants from infection and reduce parasite egg production. This offers a realistic prospect for a commercial vaccine to lower disease transmission in livestock.
Area of Science:
- Veterinary Parasitology
- Ruminant Health
- Infectious Disease Control
Background:
- Fasciola spp infections in ruminants cause significant global economic losses.
- Current control relies heavily on anthelmintics, facing resistance issues.
- Vaccination with defined Fasciola antigens shows promise for protection.
Purpose of the Study:
- To review recent vaccine trials against Fasciola spp in ruminants.
- To discuss the potential of vaccination to reduce parasite burdens and egg production.
- To explore future prospects and challenges in developing a commercial Fasciola vaccine.
Main Methods:
- Review of published vaccine trial data.
- Analysis of immune responses elicited by Fasciola antigens.
- Evaluation of vaccine efficacy in reducing fluke burdens and egg counts.
Main Results:
- Several vaccine trials demonstrate significant protection against Fasciola infection.
- Vaccination can reduce both fluke burdens and parasite egg production.
- Concurrent reduction in egg production suggests potential for reduced transmission.
Conclusions:
- Vaccination with defined Fasciola antigens is a viable strategy for ruminant health.
- Commercial vaccines could reduce economic losses and parasite transmission.
- Further research is needed to overcome existing hurdles for field application.
