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Related Experiment Videos

How does Trichinella spiralis make itself at home?

D D Despommier1

  • 1Division of Environmental Health Sciences and Department of Microbiology, Columbia University, 630 West 168th St, New York City, NY 10032, USA.

Parasitology Today (Personal Ed.)
|October 17, 2006
PubMed
Summary

Trichinella spiralis larvae create a unique nurse cell-parasite complex within muscle cells. Secreted larval proteins are hypothesized to reprogram host cell gene expression, driving nurse cell development.

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Trichinella spiralis: vascular endothelial growth factor is up-regulated within the nurse cell during the early phase of its formation.

The Journal of parasitology·1998
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Trichinella spiralis: synthesis of type IV and type VI collagen during nurse cell formation.

Experimental parasitology·1997
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Developmental expression of a 43-kDa secreted glycoprotein from Trichinella spiralis.

Molecular and biochemical parasitology·1996
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Trichinella pseudospiralis secretes a protein related to the Trichinella spiralis 43-kDa glycoprotein.

Molecular and biochemical parasitology·1996
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Clinical aspects of infection with Trichinella spp.

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A method for isolation and partial purification of Trichinella spiralis nurse cells.

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Area of Science:

  • Parasitology
  • Cell Biology
  • Molecular Biology

Background:

  • The nurse cell-parasite complex formed by Trichinella spiralis is a unique biological structure.
  • This complex develops from striated skeletal muscle cells within 15-20 days post-larval invasion.

Purpose of the Study:

  • To propose a hypothesis explaining the molecular mechanisms behind nurse cell-parasite complex formation.
  • To investigate the role of secreted larval proteins in this process.

Main Methods:

  • Hypothetical model proposed by Dickson Despommier.
  • Focus on secreted tyvelosylated proteins from the larva.

Main Results:

  • Secreted larval proteins are present in the intracellular niche from Day 7 post-infection.

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  • These proteins are hypothesized to redirect host genomic expression, initiating nurse cell formation.

    • Conclusions:

    • Tyvelosylated proteins secreted by Trichinella spiralis larvae are central to nurse cell formation.
    • These proteins likely reprogram host muscle cells to create a specialized intracellular niche.