Related Experiment Video
Updated: Jul 19, 2026
12:05
Mass Isolation and In Vitro Cultivation of Intramolluscan Stages of the Human Blood Fluke Schistosoma Mansoni
Published on: January 14, 2018
Schistosomiasis: forty years' war on the worm
1Pasteur Institut de Lille, 1 rue du Prof. A. Calmette, BP 245, 59019 Lille Cedex, France.
Parasitology Today (Personal Ed.)
|October 17, 2006
Summary
Schistosomiasis vaccine candidates are advancing to clinical trials, marking significant progress in immunointervention. This evolution stems from integrating biology, epidemiology, and biotechnology for disease control.
Area of Science:
- * Parasitology and Tropical Medicine
- * Immunology and Vaccine Development
Background:
- * Schistosomiasis remains a major global health concern, necessitating novel control strategies.
- * Previous efforts in schistosomiasis control have been limited, highlighting the need for innovative approaches.
Purpose of the Study:
- * To review advancements in schistosomiasis control and the development of potential vaccines.
- * To illustrate the evolution of concepts and tools in the fight against schistosomiasis.
Main Methods:
- * Comprehensive review of major findings and observations in schistosomiasis research.
- * Integration of knowledge from biology, epidemiology, and biotechnology.
Main Results:
- * Significant evolution in understanding schistosomiasis and developing control strategies.
- * Production of novel and promising tools for schistosomiasis intervention.
- * Schistosome vaccine candidates are now entering Phase I clinical trials.
Conclusions:
- * The integration of diverse scientific knowledge has driven progress in schistosomiasis control.
- * Current clinical trials represent a crucial step towards immunointervention for human schistosomiasis.
- * While outcomes are uncertain, advancements offer hope for effective vaccine-based interventions.
Related Concept Videos
01:12Giardiasis
Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
01:15Anthelminthic Agents
Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
00:58Symbiosis
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
01:18Trichomoniasis
Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.
01:22American Trypanosomiasis
Chagas disease, or American trypanosomiasis, is a vector-borne parasitic infection caused by Trypanosoma cruzi, a flagellated protozoan (kinetoplastid) of the family Trypanosomatidae. The disease is endemic in Latin America, although cases are increasingly reported worldwide due to human migration. Transmission most commonly occurs when feces of infected triatomine bugs contaminate bite wounds or mucosal surfaces; additional routes include congenital, transfusional, transplant-related, and oral...