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Related Concept Videos

Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...

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Related Experiment Video

Updated: Jul 19, 2026

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

Osteoporotic vertebral compression fracture causing neurologic deficit.

Marcel Weber1, Kurt Uehlinger, Heini Gerber

  • 1Department of Rheumatology and Rehabilitation, Triemli Hospital, Zürich, Switzerland. marcel.weber@triemli.stzh.ch

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|October 17, 2006
PubMed
Summary

Osteoporotic vertebral fractures can cause neurologic deficits, though rare. This case highlights a 69-year-old man with L5 nerve root impairment due to a lumbar vertebral fracture, emphasizing the importance of recognizing these neurological complications.

Related Experiment Videos

Last Updated: Jul 19, 2026

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

Area of Science:

  • Neurology
  • Orthopedics
  • Geriatrics

Background:

  • Osteoporotic vertebral fractures (OVFs) are common in the elderly.
  • Neurologic deficits secondary to OVFs are infrequent but can be severe.
  • Hypogonadism is a risk factor for osteoporosis and subsequent fractures.

Purpose of the Study:

  • To present a case of neurologic deficit from an OVF.
  • To review the literature on neurologic complications of OVFs.
  • To emphasize the diagnostic and management considerations for these rare events.

Main Methods:

  • Case report of a 69-year-old male with L5 nerve root dysfunction.
  • Review of 64 cases of neurologic deficit associated with OVFs from literature.
  • Analysis of fracture locations, symptoms, and treatment outcomes.

Main Results:

  • The patient presented with left L5 nerve root impairment due to a lumbar vertebral fracture with spinal canal protrusion.
  • Most OVFs with neurologic deficit occur at the thoracolumbar junction (72%).
  • Neurologic deficits can be progressive and may mimic abdominal or renal pain.

Conclusions:

  • OVFs can cause significant neurologic deficits, necessitating prompt diagnosis and management.
  • Surgical intervention often leads to remission of neurologic symptoms.
  • Increased incidence of OVFs in aging populations makes awareness of neurologic complications crucial.