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Persistent hiccups associated with intravenous corticosteroid therapy.
Yao-Min Hung1, Michael A Miller, Manish M Patel
1Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Summary
Hiccups (singultus) can be a disabling side effect of medications. This case series highlights 5 instances where intravenous corticosteroids caused persistent hiccups, urging physician awareness.
Area of Science:
- Pharmacology
- Gastroenterology
- Neurology
Background:
- Singultus (hiccups) are typically idiopathic and transient.
- Persistent hiccups can significantly impair quality of life.
- Medications are recognized, though less common, causes of hiccups.
Purpose of the Study:
- To report a series of patients experiencing hiccups associated with intravenous corticosteroid use.
- To raise awareness among healthcare providers regarding this potential adverse drug reaction.
Main Methods:
- Case series methodology.
- Analysis of 5 patient cases reported to an adverse drug reaction system.
- Data collected between January 1998 and December 2000.
Main Results:
- Five patients developed persistent hiccups after receiving intravenous corticosteroids.
- The association between corticosteroid administration and hiccup onset was noted.
Conclusions:
- Intravenous corticosteroids are an uncommon but potential cause of persistent hiccups.
- Physicians should consider corticosteroids as a possible etiology in patients presenting with new-onset hiccups.
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