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Published on: July 13, 2018
A cost-effective modified micromethod for measuring urine iodine
Hussain Husniza1, Wan Mohamud Wan Nazaimoon
1Cardiovascular, Diabetes & Nutrition Research Centre, Institute for Medical Research (IMR), Kuala Lumpur, Malaysia.
Tropical Biomedicine
|October 17, 2006
Summary
A new urine iodine micromethod was developed and validated, showing high accuracy and precision. This method offers a reliable tool for assessing iodine status in populations.
Area of Science:
- Biochemistry
- Analytical Chemistry
- Public Health
Background:
- Accurate measurement of urinary iodine is crucial for assessing iodine status and monitoring public health interventions.
- Existing methods may require large sample volumes or specialized equipment, limiting widespread application.
Purpose of the Study:
- To establish and validate a modified micromethod for measuring urine iodine.
- To assess the accuracy, precision, and reliability of the developed micromethod.
Main Methods:
- A modified micromethod for urine iodine measurement was established.
- Validation involved comparison with a World Health Organization (WHO) reference method.
- Assessed parameters included correlation, agreement, sensitivity, recovery, linearity, and coefficients of variation (CVs).
Main Results:
- The micromethod demonstrated good correlation (r=0.962) and agreement with the WHO reference method.
- Sensitivity was determined to be 13.809 ug/L.
- Mean recoveries ranged from 103-114% across tested concentrations, with intra- and inter-assay CVs generally below 15%.
Conclusions:
- The modified micromethod is a valid and reliable tool for measuring urine iodine.
- Its accuracy, precision, and sensitivity support its use in public health programs for iodine status assessment.
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