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Updated: Jul 19, 2026

Amplification of Near Full-length HIV-1 Proviruses for Next-Generation Sequencing
Published on: October 16, 2018
Genomics meets HIV-1
Amalio Telenti1, David B Goldstein
1Institute of Microbiology, University Hospital, University of Lausanne, 1011 Lausanne, Switzerland. amalio.telenti@chuv.ch
Abstract:
Genomics is now a core element in the effort to develop a vaccine against HIV-1. Thanks to unprecedented progress in high-throughput genotyping and sequencing, in knowledge about genetic variation in humans, and in evolutionary genomics, it is finally possible to systematically search the genome for common genetic variants that influence the human response to HIV-1. The identification of such variants would help to determine which aspects of the response to the virus are the most promising targets for intervention. However, a key obstacle to progress remains the scarcity of appropriate human cohorts available for genomic research.
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