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Updated: Jul 19, 2026
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Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
Published on: December 3, 2017
[Histopathological diagnostics in endoprosthesis loosening].
L Morawietz1, T Gehrke, J H Schröder
1Institut für Pathologie, Charité Universitätsmedizin, Berlin. lars.morawietz@charite.de
Der Pathologe
|October 17, 2006
Summary
Total joint replacement surgery is common, but 5-12% of implants fail within 10 years. This study defines histomorphological criteria for diagnosing periprosthetic membranes, aiding in understanding implant loosening.
Area of Science:
- Orthopedic surgery
- Pathology
- Biomaterials science
Context:
- Total joint endoprostheses are implanted 1.5 million times annually worldwide.
- Indications include osteoarthritis, rheumatic diseases, trauma, and bone neoplasia.
- 5-12% of patients experience pain and impaired function within 10 years, requiring revision surgery.
Purpose:
- To elucidate defined histomorphological criteria for standardized diagnostics of periprosthetic membranes.
- To present a recently established classification system for periprosthetic membrane evaluation.
- To clarify the pathogenetic impact of the periprosthetic membrane on implant loosening.
Summary:
- Periprosthetic membranes, removed during revision surgery, are connective tissues implicated in implant loosening.
- Histopathological evaluation of these membranes is crucial for understanding failure mechanisms.
- This article details standardized diagnostic criteria based on a new classification system.
Impact:
- Standardized diagnostics can improve the understanding of implant failure.
- Histopathological analysis of periprosthetic membranes may guide future implant design and surgical techniques.
- Enhanced diagnostic criteria can contribute to reducing revision surgery rates.
