Acute and late genitourinary toxicity of conformal radiotherapy for prostate cancer
Related Experiment Video
Updated: Jul 19, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Ryo-ichi Yoshimura1, Masaru Iwata, Hitoshi Shibuya
1Department of Radiology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. ysmrmrad@tmd.ac.jp
Purpose:
The aim of this study was to identify predictive factors for genitourinary (GU) toxicity in prostate cancer patients who underwent conformal radiotherapy (CRT).
Materials And Methods:
In this study we analyzed 154 cases of T1-3N0M0 prostate adenocarcinoma and evaluated the occurrence rate of acute and late GU toxicity and the duration of acute toxicity according to clinical parameters: age, transurethral resection of the prostate prior to CRT, hormone therapy, CRT dose, length of planning target volume (PTV).
Results:
Altogether, 41% of the patients developed grade 2 or higher acute GU toxicity. Longer PTV was significantly associated with a higher incidence of acute GU toxicity (>7 cm, 53%;
Conclusion:
The length of PTV and hormone therapy were predictive factors for acute GU toxicity. Furthermore, acute GU toxicity was the most important predictive factor for late GU toxicity.
Related Concept Videos
Nursing Assessment of the Genitourinary System I: Health History
Imaging Studies III: Computed Tomography
Kidney Transplant II: Surgical Procedure
Acute Kidney Injury II: Pathophysiology
Disorders of the Male Reproductive System
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Acute Kidney Injury III: Clinical Manifestations
