Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exocrine pancreatic function in chronic liver diseases.

T Hayakawa1, T Kondo, T Shibata

  • 1Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.

The American Journal of Gastroenterology
|February 1, 1991
PubMed
Summary

Chronic alcoholism significantly impacts exocrine pancreatic function, increasing secretion volume and output, especially in alcoholic liver cirrhosis. However, severe chronic pancreatitis is not directly correlated with liver disease severity in these patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomized, double-blind, placebo-controlled phase II study of olanzapine-based prophylactic antiemetic therapy for delayed and persistent nausea and vomiting in patients with HER2-positive or HER2-low breast cancer treated with trastuzumab deruxtecan: ERICA study (WJOG14320B).

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

Identifying prognostic biomarkers for palbociclib add-on therapy in fulvestrant-resistant breast cancer using cell-free DNA sequencing.

ESMO open·2024
Same author

Publisher Correction: The understanding of congruent and incongruent referential gaze in 17-month-old infants: an eye-tracking study comparing human and robot.

Scientific reports·2020
Same author

The understanding of congruent and incongruent referential gaze in 17-month-old infants: an eye-tracking study comparing human and robot.

Scientific reports·2020
Same author

Network meta-analysis of the relative efficacy of bariatric surgeries for diabetes remission.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2018
Same author

Role of fatty liver in the association between obesity and reduced hepatic insulin clearance.

Diabetes & metabolism·2018

Area of Science:

  • Gastroenterology
  • Hepatology
  • Pancreatology

Background:

  • Chronic alcoholism and liver disease are common conditions with potential impacts on exocrine pancreatic function.
  • Understanding the distinct roles of alcohol and liver damage in pancreatic dysfunction is crucial for patient management.

Purpose of the Study:

  • To investigate the specific influences of chronic alcoholism and liver disease on exocrine pancreatic function.
  • To compare pancreatic function in patients with alcoholic and nonalcoholic liver disease, both cirrhotic and non-cirrhotic.

Main Methods:

  • Performed cholecystokinin secretin (CS) tests on four patient subgroups: alcoholic liver cirrhosis (ALC), alcoholic non-cirrhotic liver disease (AnLC), nonalcoholic liver cirrhosis (nALC), and nonalcoholic non-cirrhotic liver disease (nAnLC).
  • Analyzed duodenal juice volume, bicarbonate output (BO), maximal bicarbonate concentration, and amylase output (AO).

Related Experiment Videos

  • Assessed correlation between indocyanine green (ICG) excretion rate and CS test parameters.

    • Main Results:

    • Alcoholic liver disease patients (ALC) showed increased duodenal juice volume and BO, with decreased maximal bicarbonate concentration compared to controls.
    • In alcoholic liver disease, both volume and BO were higher in cirrhotic (LC) than non-cirrhotic (nLC) patients; this was not observed in nonalcoholic liver disease.
    • A significant correlation was found between liver function (ICG excretion) and pancreatic secretion parameters in alcoholic liver disease, but not in nonalcoholic liver disease. Chronic pancreatitis was infrequent and not correlated with liver disease severity.

    Conclusions:

    • Chronic alcoholism, particularly in the context of liver cirrhosis, significantly alters exocrine pancreatic function, leading to increased secretion.
    • Liver disease severity in alcoholic patients correlates with increased exocrine pancreatic secretion, but not necessarily with the presence of chronic pancreatitis.
    • The impact of liver disease on exocrine pancreatic function is distinct between alcoholic and nonalcoholic etiologies.