Related Experiment Video
Updated: Jul 19, 2026

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
Published on: June 23, 2018
[Chemical modification of heparin]
Abstract:
Heparin was modified at carboxyl groups by reaction with several pharmacologically important amino-containing compounds in aqueous medium in the presence of 1-ethyl-3-[3-(dimethylamino)propyl]carbodiimide. In dependence on the nature of the amine and the ratio of reagents, conjugates containing 36-100% amide and 0-25% isoureidocarbonyl groups were synthesized. Isoureidoarylamide groups are present, along with amide moieties, in the products of heparin modification by hydroxyl-containing aromatic amines. The conjugate of heparin with p-aminobenzoic acid contained oligomeric arylamide.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein.
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Phase II Reactions: Sulfation and Conjugation with α-Amino Acids
EDTA: Chemistry and Properties
Venous Thrombosis III: Interprofessional Care

