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Serum and urine concentrations of trypsinogen-activation peptide as markers for acute pancreatitis in cats

Heidi S Allen1, Jörg Steiner, John Broussard

  • 1The Bobst Hospital, Animal Medical Center, New York, New York 10021, USA. RUN.DVM@Verizon.net

Canadian Journal of Veterinary Research = Revue Canadienne De Recherche Veterinaire
|October 18, 2006
PubMed

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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
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