Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Tenascin expression in hyperproliferative skin diseases.

J Schalkwijk¹, I Van Vlijmen, B Oosterling

¹Department of Dermatology, University Hospital Nijmegen, The Netherlands.

The British Journal of Dermatology

|January 1, 1991

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Mapping of Dietary Interventions Beneficial in the Prevention of Secondary Health Conditions in Spinal Cord Injured Population: A Systematic Review.

The journal of nutrition, health & aging·2023

Same author

Protease-activated receptor-2 promotes osteogenesis in skeletal mesenchymal stem cells at the expense of adipogenesis: Involvement of interleukin-6.

Bone reports·2021

Same author

Fully endoscopic clipping of anterior circulation cerebral aneurysms through transpalpebral approach: One step closer to robotic neurovascular surgery?

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2021

Same author

Management of vascular and nonvascular complications following pancreas transplantation with interventional radiology.

Diagnostic and interventional imaging·2020

Same author

Minilaparotomy-assisted transmesenteric approach for portal vein recanalization and transjugular intrahepatic portosystemic shunt in a non-cirrhotic patient with portal cavernoma.

Diagnostic and interventional imaging·2020

Same author

Disrupted type II collagenolysis impairs angiogenesis, delays endochondral ossification and initiates aberrant ossification in mouse limbs.

Matrix biology : journal of the International Society for Matrix Biology·2019

Tenascin, an extracellular matrix glycoprotein, shows varied expression in normal skin but is significantly upregulated in hyperproliferative skin diseases like psoriasis and basal cell carcinoma, differing from other matrix components.

Area of Science:

Dermatology
Cell Biology
Biochemistry

Background:

Tenascin is a recently discovered extracellular matrix glycoprotein.
Its role in normal and diseased skin requires further elucidation.

Purpose of the Study:

To investigate the expression patterns of tenascin in normal human skin.
To analyze tenascin distribution in skin conditions characterized by epidermal hyperproliferation.

Main Methods:

Immunohistochemistry was employed to detect tenascin expression.
The study included normal skin and various hyperproliferative skin diseases: psoriasis, basal cell carcinoma, Bowen's disease, and solar keratosis.

Main Results:

Normal skin exhibited variable tenascin expression in the upper dermis, with intense staining around adnexal structures.

Related Experiment Videos

Marked tenascin expression was observed in the stroma of basal cell carcinoma, adjacent to tumor nests.

In Bowen's disease and solar keratosis, tenascin was present in the dermis near keratinocytes.

Psoriatic skin showed intense staining in dermal papillae and a continuous band along the basal membrane.

Conclusions:

Tenascin expression is significantly altered in hyperproliferative skin diseases.
Its distribution pattern in these conditions differs from other known extracellular matrix components.
Tenascin may play a role in the pathogenesis of these skin diseases.