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Updated: Jul 19, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
Cognitive-behavioral therapy for bipolar disorders in adolescents: a pilot study
Norah C Feeny1, Carla Kmett Danielson, Lisa Schwartz
1Department of Psychiatry, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, Cleveland, OH 44106, USA. norah.feeny@case.edu
Objectives:
To develop a cognitive behavioral intervention for adolescents with bipolar disorders, test its feasibility and preliminary efficacy.
Methods:
Based on existing research, a manualized, individually delivered cognitive behavioral intervention was developed and tested with adolescents with bipolar disorders as an adjunct to pharmacological treatment. Using existing data, baseline characteristics and outcome were compared to a matched group of eight adolescents with bipolar disorders who did not receive any psychosocial intervention.
Results:
Preliminary results support the feasibility and efficacy of this manualized cognitive behavioral intervention.
Conclusions:
Individually delivered cognitive-behavioral therapy (CBT) as an adjunct to pharmacological treatment is feasible and associated with symptom improvement in adolescents with bipolar disorders. Randomized controlled studies are needed.
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