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Effects of trolox on nerve dysfunction, thermal hyperalgesia and oxidative stress in experimental diabetic neuropathy

Shyam S Sharma1, Sufyan G Sayyed

  • 1Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Punjab, India. ssharma@niper.ac.in

Clinical and Experimental Pharmacology & Physiology
|October 18, 2006
PubMed

Insights

Trolox, an antioxidant, effectively combats oxidative stress in diabetic neuropathy. This study shows trolox improves nerve function and reduces pain in diabetic rats, suggesting its therapeutic potential.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pharmacology

Background:

  • Diabetic neuropathy is a common diabetes complication.
  • Oxidative stress is a key factor in its development.
  • Experimental models are crucial for studying diabetic neuropathy.

Purpose of the Study:

  • To investigate the role of oxidative stress in streptozotocin-induced diabetic neuropathy in rats.
  • To evaluate the efficacy of trolox, an antioxidant, in treating experimental diabetic neuropathy.
  • To assess the impact of trolox on nerve function, pain, and oxidative stress markers.

Main Methods:

  • Induction of diabetes and neuropathy in rats using streptozotocin.
  • Administration of trolox (10 and 30 mg/kg) for two weeks.
  • Assessment of motor nerve conduction velocity (MNCV), nerve blood flow (NBF), and thermal hyperalgesia.
  • Measurement of antioxidant enzyme activity and lipid peroxidation in sciatic nerves.

Main Results:

  • Diabetic rats exhibited significant deficits in MNCV, NBF, and thermal sensitivity.
  • Elevated lipid peroxidation and reduced antioxidant enzyme activity were observed in diabetic rat sciatic nerves.
  • Trolox treatment significantly improved MNCV, NBF, and thermal hyperalgesia.
  • Trolox administration normalized antioxidant enzyme activity and reduced lipid peroxidation.

Conclusions:

  • Oxidative stress plays a significant role in the pathophysiology of experimental diabetic neuropathy.
  • Trolox demonstrates beneficial effects in ameliorating diabetic neuropathy in rats.
  • Trolox holds promise as a potential therapeutic agent for diabetic neuropathy.

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