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Beaver fever arthritis.

Daniel W Carlson1, David R Finger

  • 1From the Department of Medicine and the Rheumatology Service, Tripler Army Medical Center, Honolulu, Hawaii, USA. david.finger@haw.tamc.amedd.army.mil

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|October 18, 2006
PubMed
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Giardia lamblia can cause reactive arthritis (ReA), a type of inflammatory joint condition. Early recognition of Giardia infection as a cause of ReA is crucial for effective treatment.

Area of Science:

  • Infectious Diseases
  • Rheumatology
  • Immunology

Background:

  • Giardia lamblia is a common cause of gastroenteritis.
  • Reactive arthritis (ReA) is an inflammatory joint condition.
  • Giardia lamblia is a rare but reported cause of ReA.

Purpose of the Study:

  • To report a case of inflammatory oligoarthritis secondary to Giardia infection.
  • To review previously reported cases of ReA following giardiasis.
  • To discuss potential pathogenic mechanisms of Giardia-induced ReA.

Main Methods:

  • Case report of a young woman with inflammatory oligoarthritis after Giardia infection.
  • Review of existing literature on ReA associated with Giardiasis.
  • Clinical and laboratory data analysis including serological and genetic markers.

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Main Results:

  • The patient presented with inflammatory arthritis of the knee and elbow, unresponsive to NSAIDs.
  • Negative results for antinuclear antibody, rheumatoid factor, and HLA-B27.
  • Complete symptom resolution following intraarticular corticosteroid injection.

Conclusions:

  • Giardia infection should be considered in the differential diagnosis of ReA, even when less common.
  • Awareness of Giardia as a potential trigger for ReA has diagnostic and therapeutic implications.
  • Understanding pathogenic mechanisms may improve management of non-chlamydial and non-bacterial gastroenteritis-associated ReA.