Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basic science for the clinician 28: T-helper cell subtypes.

Leonard H Sigal1

  • 1From the Pharmaceutical Research Institute-Bristol-Myers Squibb, Princeton, New Jersey, and the Division of Rheumatology and Connective Tissue Research, the Departments of Medicine, Pediatrics, and the Molecular Genetics & Microbiology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Princeton, New Jersey.

Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases
|October 18, 2006
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aspects of the Immunopathogenesis of Lyme Arthritis.

Microorganisms·2025
Same author

Proposed Immunopathogenetic Mechanisms Underlying Lyme Arthritis.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2024
Same author

Autobiographical Case Report: A Rubber Band, a Glass of Orange Juice.

Cureus·2021
Same author

What is causing the 'long-hauler' phenomenon after COVID-19?

Cleveland Clinic journal of medicine·2021
Same author

Enhanced Adhesion and OspC Protein Synthesis of the Lyme Disease Spirochete Borrelia Burgdorferi Cultivated in a Host-Derived Tissue Co-Culture System.

Balkan medical journal·2014
Same author

Basic science for the clinician 59: polymorphonuclear cells: mechanisms in human defense and in the pathogenesis of autoimmune disease.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases·2012

The immune system uses innate and acquired responses, involving cellular and humoral immunity, to fight invaders. T-helper cells (CD4), specifically TH1 and TH2 subtypes, are crucial in directing these immune responses.

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • The immune system comprises innate and acquired responses with overlapping functions.
  • Cellular immunity targets intracellular pathogens, while humoral immunity targets extracellular pathogens using antibodies.
  • T-helper cells (CD4) are central to orchestrating immune response type.

Purpose of the Study:

  • To discuss the roles of T-helper cell subtypes in directing immune responses.
  • To explore the cytokines involved in cellular and humoral immunity.
  • To examine how immune response balance impacts health and disease.

Main Methods:

  • Review of immunological principles.
  • Discussion of T-helper cell subtypes (TH1 and TH2).
  • Analysis of cytokine profiles and their effects.

Related Experiment Videos

Main Results:

  • TH1 cells promote cellular immune responses.
  • TH2 cells promote humoral immune responses.
  • Cytokine balance is critical for maintaining immune homeostasis.

Conclusions:

  • T-helper cells (CD4) are key decision-makers in immune response pathways.
  • Dysregulation of cytokine balance can lead to immune-related pathologies.
  • Understanding these balances is vital for immune health.