Related Experiment Video
Updated: Jul 19, 2026
09:39
Normal and Malignant Muscle Cell Transplantation into Immune Compromised Adult Zebrafish
Published on: December 26, 2014
Skeletal muscle translocation in vertebrates.
Darrell J R Evans1, Petr Valasek, Corina Schmidt
1Brighton and Sussex Medical School, University of Sussex, Brighton, UK.
Anatomy and Embryology
|October 18, 2006
Summary
Muscle development originates from somites, not local sources. Cells migrate via epithelial to mesenchymal transition or sheet movement, crucial for head and body muscle formation.
Area of Science:
- Developmental biology
- Cell biology
- Anatomy
Background:
- Overturned the prevailing view of local muscle development.
- Identified somite origin of limb musculature.
- Described epithelial to mesenchymal transition for cell migration.
Purpose of the Study:
- To describe muscle formation in head and body using translocatory mechanisms.
- To highlight the complexity of muscle translocation.
- To utilize muscle translocation as a tool for studying tissue patterning.
Main Methods:
- Electron microscopy
- Histological procedures
Main Results:
- Demonstrated somite origin of limb musculature.
- Identified epithelial to mesenchymal transition as a key mechanism for myogenic cell translocation.
- Highlighted cell sheet movement as another translocation mechanism.
- Showcased the complexity of muscle translocation processes.
Conclusions:
- Muscle development relies on cell translocation from somites.
- Muscle translocation is a complex, versatile developmental process.
- Understanding muscle translocation aids in studying tissue patterning and development.
Related Concept Videos
00:55Skeletal Muscle Anatomy
Skeletal muscle is the most abundant type of muscle in the body. Tendons are the connective tissue that attaches skeletal muscle to bones. Skeletal muscles pull on tendons, which in turn pull on bones to carry out voluntary movements.
01:18Axial and Appendicular Muscles
Skeletal muscles, the key players in our body's movement, can be classified into two groups based on their location and function: axial muscles and appendicular muscles. These classifications reflect the primary roles the muscles play in the body's structure and movement.
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and play a...
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and play a...
01:18The Muscular System
The muscular system is essential to the body's overall structure and function, playing a crucial role in movement, stability, and internal processes. It consists of three distinct types of muscle tissue: the skeletal, the smooth, and the cardiac muscles.
01:25Fascicle Arrangement in Skeletal Muscles
Fascicles are bundles of muscle fibers in a skeletal muscle. Muscle fascicle arrangement is directly associated with the power and range of motion of various muscles. The configuration of these fascicles can vary, leading to different functional outcomes.
The four primary types of muscle based on fascicle arrangement are:
The four primary types of muscle based on fascicle arrangement are:
01:15Overview of Skeletal Muscle
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
01:21Satellite Stem Cells and Muscular Dystrophy
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...