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Progress in development and testing of novel recombinant vaccine platforms for HIV

David B Weiner1

  • 1Pathology and Laboratory Medicine, Gene Therapy and Vaccines Program, CAMB, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. dbweiner@mail.med.upenn.edu

Springer Seminars in Immunopathology
|October 18, 2006
PubMed
Abstract

No abstract available in PubMed .

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Vaccine Production

Vaccine production involves a sequence of upstream and downstream processes to generate a safe and effective immunological product. It begins with cultivating microorganisms, such as viruses or bacteria, to obtain antigenic material. For viral vaccines, mammalian host cells are grown in bioreactors and subsequently infected with the target virus. The virus replicates within the host cells, which are lysed to release viral particles. This lysate is then clarified through filtration or...

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