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Related Experiment Videos

IGF1, growth pathway polymorphisms and schizophrenia: a pooling study.

D Gunnell1, S Lewis, J Wilkinson

  • 1Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK. D.J.Gunnell@Bristol.ac.uk

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
|October 18, 2006
PubMed
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This study investigated the link between insulin-like growth factors (IGFs) and schizophrenia. Genetic analysis found no association, suggesting IGF-I does not play a major role in schizophrenia development.

Area of Science:

  • Neurogenetics
  • Endocrinology
  • Psychiatric Genetics

Background:

  • Associations between poor fetal/childhood growth and schizophrenia suggest a role for the growth hormone (GH)-insulin-like growth factor (IGF) axis.
  • Investigating genetic factors within this axis is crucial for understanding schizophrenia etiology.

Purpose of the Study:

  • To examine the association between schizophrenia and single nucleotide polymorphisms (SNPs) in the IGF1 gene.
  • To investigate the relationship between schizophrenia and functional polymorphisms in key GH-IGF pathway genes: IGF1R, IRS1, GH1, and IGFBP3.

Main Methods:

  • Analysis of 16 SNPs across the IGF1 gene in UK/Irish schizophrenia cases (n=648) and controls (n=712).
  • Examination of 4 common functional polymorphisms in IGF1R, IRS1, GH1, and IGFBP3.

Related Experiment Videos

  • Replicated pooled DNA analyses and study of 297 Bulgarian parent-offspring trios.

    • Main Results:

    • No significant association was found between schizophrenia and any of the 16 SNPs within the IGF1 gene.
    • No association was detected for the 4 key SNPs in the other investigated GH-IGF pathway genes.
    • Extensive SNP coverage of IGF1 was achieved.

    Conclusions:

    • The findings do not support a major role for Insulin-like Growth Factor 1 (IGF-I) in the etiology of schizophrenia.
    • Genetic variations in the examined GH-IGF pathway genes are unlikely to be a primary factor in schizophrenia development.