Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulating p73 isoforms in human tumours.

P J Coates1

  • 1Pathology and Neurosciences, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK. p.j.coates@dundee.ac.uk

The Journal of Pathology
|October 18, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intrinsic proteotoxic stress levels vary and act as a predictive marker for sensitivity of cancer cells to Hsp90 inhibition.

PloS one·2018
Same author

[Application of PLA Method for Detection of p53/p63/p73 Complexes in Situ in Tumour Cells and Tumour Tissue].

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti·2017
Same author

Expression of p16 in squamous cell carcinoma of the mobile tongue is independent of HPV infection despite presence of the HPV-receptor syndecan-1.

British journal of cancer·2015
Same author

Downregulation of miRNA-424: a sign of field cancerisation in clinically normal tongue adjacent to squamous cell carcinoma.

British journal of cancer·2015
Same author

Viruses and disease: emerging concepts for prevention, diagnosis and treatment.

The Journal of pathology·2014
Same author

Lack of correlation of stem cell markers in breast cancer stem cells.

British journal of cancer·2014
Same journal

Tumor Invasive Border Index (TIBI) in colorectal cancer: linking infiltrative morphology to molecular insights.

The Journal of pathology·2026
Same journal

Lipodystrophy and adipose tissue recovery are mediated by the Wnt/lipogenesis axis during skin fibrosis.

The Journal of pathology·2026
Same journal

Optical mapping reveals a higher level of large-scale structural variants in a family with paternally transmitted myotonic dystrophy and independent Parkinson's disease.

The Journal of pathology·2026
Same journal

FTO-mediated m6A modification of protein disulfide-isomerase activates VEGFA-VEGFR2 to suppress programmed cell death in osteosarcoma.

The Journal of pathology·2026
Same journal

Dopamine inhibits retinal pathological neovascularization in the oxygen-induced retinopathy mouse model.

The Journal of pathology·2026
Same journal

Aberrant alternative splicing of purinergic receptor P2RX4 prevents sensitivity towards combinatorial treatment in colorectal and pancreatic cancer.

The Journal of pathology·2026
See all related articles

Altered expression of the TP73 gene, not mutations, is common in tumors. The balance between TP73 isoforms (TAp73 and DeltaTAp73) is key, influencing cancer development and chemosensitivity.

Area of Science:

  • Molecular Biology
  • Cancer Genetics
  • Tumorigenesis

Background:

  • Mutations in the TP73 gene are rare in human tumors, but altered expression is frequent.
  • TP73 exhibits dual roles: tumor suppressor (reduced expression in leukemias/lymphomas) and oncogene (over-expressed in other tumors).
  • The TP73 gene encodes both p53-like (TAp73) and anti-p53 (DeltaTAp73) isoforms, suggesting isoform balance is critical.

Purpose of the Study:

  • To investigate the regulatory mechanisms of TP73 isoform expression.
  • To understand the role of TP73 isoform balance in human tumorigenesis.
  • To explore the clinical implications of TP73 regulation in cancer, particularly colorectal cancer.

Main Methods:

  • Analysis of TP73 gene expression patterns in various tumor types.

Related Experiment Videos

  • Investigation of regulatory factors including ZEB1, p300, and a specific intron 1 polymorphism.
  • Correlation of TP73 regulatory pathway alterations with clinico-pathological characteristics in colorectal cancer.

    • Main Results:

    • The balance between TAp73 and DeltaTAp73 isoforms is crucial for oncogenic transformation.
    • ZEB1, p300, and a 73 bp deletion in TP73 intron 1 are implicated in regulating TP73 isoform expression.
    • Aberrant TP73 isoform regulation in colorectal cancer is linked to adverse clinico-pathological features.

    Conclusions:

    • The interplay of TP73 isoforms and their regulators is vital in cancer development.
    • Understanding TP73 isoform regulation offers prognostic value in colorectal cancer.
    • These findings may guide future therapeutic strategies and improve patient outcomes through personalized medicine.