Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Studies on rat complement. II. Complement level in experimental tumor in rats.

M Sakamoto, K Nishioka

    The Japanese Journal of Experimental Medicine
    |June 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The role of metal allergy and local hyperhidrosis in the pathogenesis of pompholyx.

    The Journal of dermatology·1992
    Same author

    Xeroderma pigmentosum: recent clinical and photobiological aspects.

    The Journal of dermatology·1992
    Same author

    Mechanisms of desensitization in delayed cutaneous hypersensitivity--modulation of T-cell response by haptenized amino acid.

    The Journal of dermatology·1992
    Same author

    Accumulation of multiple T cell clonotypes in the synovial lesions of patients with rheumatoid arthritis revealed by a novel clonality analysis.

    International immunology·1992
    Same author

    Detection of myeloid precursors (granulocyte/macrophage colony forming units) in the bone marrow adjacent to rheumatoid arthritis joints.

    The Journal of rheumatology·1992
    Same author

    Severe progressive erosive arthritis in multicentric reticulohistiocytosis: possible involvement of cytokines in synovial proliferation.

    The Journal of rheumatology·1992
    Same journal

    Protein extractabilities from the erythrocyte membranes in patients with chorea-acanthocytosis.

    The Japanese journal of experimental medicine·1990
    Same journal

    Estrogen and progesterone receptor levels in 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors in each week--check points about experimental studies using DMBA-induced tumors.

    The Japanese journal of experimental medicine·1990
    Same journal

    Aggregated distribution of infective spots composed of Leptotrombidium pallidum, highly prevalent with Rickettsia tsutsugamushi, demonstrated by sentinel voles, Microtus montebelli, on the ground.

    The Japanese journal of experimental medicine·1990
    Same journal

    Suppression of footpad reaction in mice by anthralin.

    The Japanese journal of experimental medicine·1990
    Same journal

    Characterization and change of phospholipids in the aorta of Watanabe hereditable hyperlipidemic rabbit.

    The Japanese journal of experimental medicine·1990
    Same journal

    A new technique of in vitro assay of antifilarials using different life-forms of Acanthocheilonema viteae.

    The Japanese journal of experimental medicine·1990
    See all related articles

    Tumor growth in rats correlated with increased complement factors CIA50, C4, and C3. However, dimethylaminoazobenzene carcinogenesis initially decreased complement levels, which were restored by splenectomy, suggesting a complex role for the complement system in cancer resistance.

    Area of Science:

    • Immunology
    • Oncology
    • Biochemistry

    Background:

    • The complement system plays a crucial role in immune responses, including tumor surveillance.
    • Carcinogenesis can significantly alter complement factor levels, impacting disease progression.
    • Understanding these alterations is vital for developing effective cancer therapies.

    Purpose of the Study:

    • To investigate the dynamic changes in complement factors during chemically induced carcinogenesis in rats.
    • To explore the relationship between complement levels, tumor development, and immune status.
    • To assess the impact of splenectomy and infection on complement-mediated responses in cancer models.

    Main Methods:

    • Methylcholanthrene and dimethylaminoazobenzene were used to induce carcinogenesis in rat models.

    Related Experiment Videos

  • Complement levels, including CIA50, C4, and C3, were measured.
  • Tumor size was correlated with complement factor concentrations.
  • Effects of splenectomy and Corynebacterium infection on complement factors were analyzed.

    • Main Results:

    • Methylcholanthrene-induced tumors showed increased CIA50, C4, and C3 levels, correlating with tumor size.
    • Dimethylaminoazobenzene carcinogenesis led to decreased complement and C3 levels.
    • Splenectomized rats exposed to dimethylaminoazobenzene exhibited elevated complement system levels.
    • Corynebacterium infection resulted in increased CIA50 and C3 levels in rats.

    Conclusions:

    • Complement factors CIA50, C4, and C3 are implicated in methylcholanthrene-induced carcinogenesis.
    • The complement system's response to dimethylaminoazobenzene is complex and influenced by factors like splenectomy.
    • Elevated CIA50 and C3 following Corynebacterium infection may contribute to enhanced tumor resistance.