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Related Experiment Videos

Synaptic organization in teleost spinal motoneurons.

T Bando

    The Japanese Journal of Physiology
    |January 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Motoneuron synaptic potentials were recorded in fish pectoral fins. Ventral root stimulation revealed excitatory postsynaptic potentials (EPSPs) mediated by recurrent motoneuron axon collaterals, distinct from medullary inputs.

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    Area of Science:

    • Neuroscience
    • Motor control
    • Synaptic physiology

    Background:

    • Motoneurons control muscle activity, and their synaptic inputs are crucial for motor function.
    • Understanding the origin and properties of excitatory postsynaptic potentials (EPSPs) in motoneurons is key to deciphering motor control circuits.

    Purpose of the Study:

    • To investigate the origin and characteristics of EPSPs in motoneurons innervating pectoral fin muscles.
    • To differentiate between monosynaptic and polysynaptic pathways influencing motoneuron activity.
    • To elucidate the role of recurrent axon collaterals in motoneuron excitation.

    Main Methods:

    • Extracellular and intracellular recordings using glass microelectrodes in fish motoneurons.
    • Electrical stimulation of ventral roots, dorsal roots, and the medulla oblongata.

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  • Pharmacological blockade of cholinergic transmission using dihydro-beta-erythroidine hydrobromide and atropine sulphate.

    • Main Results:

    • Ventral root stimulation evoked EPSPs with properties suggesting monosynaptic, cholinergic input from recurrent axon collaterals.
    • Dorsal root stimulation elicited longer-latency EPSPs, indicative of polysynaptic pathways.
    • Medulla oblongata stimulation produced short-latency EPSPs, suggesting direct monosynaptic excitatory connections.
    • Facilitation of action potentials by ventral root volleys was blocked by cholinergic antagonists, confirming the neurotransmitter involved.

    Conclusions:

    • The EPSP evoked by ventral root stimulation originates from recurrent axon collaterals of motoneurons.
    • These recurrent pathways are cholinergic and likely involve peripheral dendritic sites of generation.
    • Distinct pathways from the medulla oblongata and dorsal roots provide differential excitatory input to motoneurons.