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Herpes simplex and Epstein-Barr virus lymphadenitis in a patient with chronic lymphocytic leukemia treated with

Santiago Mercadal1, Antonio Martinez, Benet Nomdedeu

  • 1Department of Hematology, Hospital Clínic, IDIBAPS, University of Barcelona, Spain. smerca@clinic.ub.es

European Journal of Haematology
|October 19, 2006
PubMed

Multiple herpes virus co-infection is a very rare complication in patients with chronic lymphocytic leukemia (CLL). We describe a patient with a CLL who developed an herpes virus lymphadenitis. Inmunohistochemical study was positive for HSV-1, HSV-2, and Epstein-Barr Virus (EBV). The coinfection of EBV with a profile of expresion of viral latent genes type III, is usually seen in inmunodepressed patients. To the best of our knowledge, this is the first reported case of a multiple human herpes virus infection mimicking Richter syndrome.

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