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Trends, perinatal characteristics, and medical conditions in pervasive developmental disorders

Pascale Guillem1, Christine Cans, Vincent Guinchat

  • 1Register for Disabled Children and the Isère County Perinatal Survey, France. pascale.guillem@imag.fr

Developmental Medicine and Child Neurology
|October 19, 2006
PubMed

Insights

The prevalence of pervasive developmental disorders (PDD) significantly increased from 1980-1993. PDD showed associations with morphogenetic anomalies and higher neonatal hospitalization rates, warranting further investigation.

Area of Science:

  • Developmental Pediatrics
  • Epidemiology
  • Child Neurology

Background:

  • Pervasive developmental disorders (PDD) represent a spectrum of neurodevelopmental conditions.
  • Understanding trends and risk factors for PDD is crucial for early intervention and public health planning.

Purpose of the Study:

  • To investigate trends in PDD prevalence.
  • To examine associations between PDD and morphogenetic anomalies.
  • To assess the relationship between PDD and perinatal factors, including neonatal hospitalization.

Main Methods:

  • Analysis of data from a French childhood disability register (1980-1993).
  • Inclusion of 454 children diagnosed with PDD at age 7, residing in Isère county.
  • Statistical analysis to determine prevalence, trends, and associations with risk factors.

Main Results:

  • Overall PDD prevalence was 22.2 per 10,000 children.
  • A significant increase in PDD prevalence was observed, rising from 14.7 to 30.8 per 10,000 during the study period.
  • Morphogenetic anomalies were present in 12.1% of children with PDD.
  • Neonatal hospitalization occurred in 22% of children with PDD, significantly higher than the general population.

Conclusions:

  • PDD prevalence has significantly increased.
  • Perinatal factors, including neonatal hospitalization, are associated with PDD.
  • Further research is needed to understand the underlying mechanisms and causes of PDD increases and associated factors.

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