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Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery disease

Ping-Ting Lin1, Chien-Hsiang Cheng, Yung-Po Liaw

  • 1School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.

Nutrition (Burbank, Los Angeles County, Calif.)
|October 19, 2006
PubMed

Insights

Low plasma pyridoxal 5'-phosphate (PLP), a marker of vitamin B6 status, is linked to increased coronary artery disease (CAD) risk. Combined low PLP and abnormal lipids further elevate this risk.

Area of Science:

  • Biochemistry
  • Cardiovascular Medicine
  • Nutritional Science

Background:

  • Vitamin B6, in its active form pyridoxal 5 '-phosphate (PLP), plays a crucial role in metabolic processes.
  • Dyslipidemia and inflammation are established risk factors for coronary artery disease (CAD).
  • The interplay between vitamin B6 status, lipid profiles, and CAD risk requires further elucidation.

Purpose of the Study:

  • To investigate the association between plasma PLP levels and lipid profiles.
  • To estimate the relationship between plasma PLP status and the risk of developing CAD.
  • To determine if lipid profiles modify the association between PLP and CAD risk.

Main Methods:

  • Case-control study design with 184 CAD patients (>=70% coronary artery stenosis) and 516 healthy controls.
  • Measurement of plasma PLP, homocysteine, high-sensitivity C-reactive protein, and comprehensive lipid profiles.
  • Statistical analysis to assess the association between PLP levels and CAD risk, adjusting for covariates.

Main Results:

  • Subjects with plasma PLP <30 nmol/L had a significantly higher risk of CAD (OR, 1.85; 95% CI, 1.16-2.95) after adjusting for homocysteine and hs-CRP.
  • The association between PLP and CAD risk remained significant after adjusting for individual lipid parameters.
  • Concomitant low PLP and abnormal lipid levels markedly amplified the risk of CAD.

Conclusions:

  • Borderline vitamin B6 deficiency (plasma PLP <30 nmol/L) is a significant risk factor for CAD.
  • The synergistic effect of low PLP and dyslipidemia substantially increases CAD risk.
  • Maintaining adequate vitamin B6 status may be important for cardiovascular health, particularly in individuals with lipid abnormalities.
Abstract

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