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Intraventricular insulin and leptin decrease sucrose self-administration in rats.

Dianne P Figlewicz1, Jennifer L Bennett, Amy MacDonald Naleid

  • 1VA Puget Sound Health Care System (151), Seattle WA 98108, United States. latte@u.washington.edu

Physiology & Behavior
|October 19, 2006
PubMed
Summary
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Central insulin and leptin administration reduce motivated food seeking. However, rats on a high-fat diet exhibit resistance to these effects, indicating potential central resistance to adiposity signals.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Behavioral Science

Background:

  • Adiposity signals like insulin and leptin are known to influence brain reward function.
  • Previous studies show these signals decrease reward function via self-stimulation and place preference.

Purpose of the Study:

  • To investigate the acute effects of central insulin and leptin on motivated food-seeking behavior.
  • To determine if a high-fat diet induces resistance to the central actions of insulin and leptin on reward.

Main Methods:

  • Rats underwent progressive ratio sucrose self-administration following central administration of insulin, leptin, or cerebrospinal fluid.
  • A separate group of rats was fed a high-fat diet for 5 weeks before testing central insulin/leptin effects.

Related Experiment Videos

Main Results:

  • Both insulin and leptin significantly reduced motivated responding (bar presses) and sucrose rewards obtained.
  • Central cerebrospinal fluid administration had no effect on motivated behavior.
  • Rats fed a high-fat diet demonstrated resistance to the suppressive effects of central insulin and leptin.

Conclusions:

  • Central insulin and leptin acutely decrease motivated food-seeking behavior, supporting their role in reward circuitry.
  • Diet-induced obesity may lead to central resistance to the effects of adiposity signals on food reward.