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Updated: Jul 19, 2026
A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
Published on: March 25, 2014
The validity of predicted T-cell epitopes
Claus Lundegaard1, Morten Nielsen, Ole Lund
1Center for Biological Sequence Analysis, BioCentrum, Building 208, Technical University of Denmark, 2800 Lyngby, Denmark. lunde@cbs.dtu.dk
Abstract:
High-performing MHC class I binding predictions have been available for more than a decade; however, their value in terms of actual epitope finding has only now been estimated in a large-scale investigation undertaken by the group of Sette. This work underlines the importance of bioinformatics as a resource-saving tool in the field of epitope discovery. In addition, the data can be used to benchmark the performance of other new or existing CTL epitope-prediction tools.
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