Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neural induction: 10 years on since the 'default model'.

Claudio D Stern1

  • 1Department of Anatomy & Developmental Biology, University College London, Gower Street, London, WC1E 6BT, UK. c.setrn@ucl.ac.uk

Current Opinion in Cell Biology
|October 19, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular basis of competence for neural induction in the chick embryo.

bioRxiv : the preprint server for biology·2026
Same author

The organizer as a cooperative of signaling cells for neural induction.

bioRxiv : the preprint server for biology·2025
Same author

Cell biology of the chick organizer: Origins, composition, population dynamics and fate.

Cells & development·2025
Same author

Canonical Wnt signalling from the area opaca induces and maintains the marginal zone in pre-primitive-streak stage chick embryos.

Development (Cambridge, England)·2025
Same author

Development and functions of the area opaca of the chick embryo.

Developmental biology·2024
Same author

The organizer and neural induction in birds and mammals.

Current topics in developmental biology·2024

Neural induction research shows ectodermal cells develop into neurons without signals, but bone morphogenetic proteins normally prevent this. Current studies reveal more complexity, focusing on gene regulation over signaling factors.

Area of Science:

  • Developmental biology
  • Molecular biology
  • Genetics

Background:

  • Neural induction is key for embryonic development, determining cell fate in the ectoderm.
  • The 'default model' proposed neural fate occurs without signals, inhibited by bone morphogenetic proteins for epidermal development.
  • Recent findings challenge this model, indicating greater complexity in neural fate determination.

Purpose of the Study:

  • To explore the complexities of neural induction beyond the 'default model'.
  • To shift focus towards understanding the nuclear regulation of gene expression in neural fate decisions.

Main Methods:

  • Analysis of gene expression patterns during neural induction.
  • Investigation of regulatory mechanisms within the nucleus controlling key genes.

Related Experiment Videos

  • Comparative studies of signaling pathways and intracellular gene regulation.

    • Main Results:

    • The 'default model' of neural induction is an oversimplification.
    • Regulation of key gene expression within the nucleus plays a critical role.
    • Intercellular signaling factors are not the sole determinants of neural fate.

    Conclusions:

    • Neural induction is a more intricate process than previously thought.
    • Understanding nuclear gene regulation is crucial for deciphering neural fate decisions.
    • Future research should prioritize the molecular mechanisms within the nucleus.