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Related Experiment Video

Updated: Jul 19, 2026

Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
08:43

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Published on: February 14, 2017

Circulating endothelial cells in cardiovascular disease.

Christopher J Boos1, Gregory Y H Lip, Andrew D Blann

  • 1Haemostasis, Thrombosis, and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom.

Journal of the American College of Cardiology
|October 19, 2006
PubMed
Summary

Quantifying circulating endothelial cells (CECs) in blood offers a new way to assess endothelial damage. Elevated CEC levels indicate cardiovascular disease risk and predict adverse outcomes after myocardial infarction.

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Phenotypic and Functional Characterization of Endothelial Colony Forming Cells Derived from Human Umbilical Cord Blood

Published on: April 13, 2012

Area of Science:

  • Cardiovascular Research
  • Endothelial Cell Biology
  • Biomarker Discovery

Background:

  • Circulating endothelial cells (CECs) are mature cells detaching from blood vessel linings due to injury.
  • Endothelial progenitor cells (EPCs) are distinct bone marrow-derived cells involved in vascular repair.
  • Assessing endothelial health is crucial for understanding and managing cardiovascular diseases.

Purpose of the Study:

  • To provide an overview of the pathophysiology of CECs in cardiovascular disease.
  • To compare CECs with EPCs.
  • To highlight the clinical relevance of CEC quantification.

Main Methods:

  • Quantification of CECs using immunomagnetic bead separation and fluorescence microscopy.
  • CEC enumeration via flow cytometry.
  • Review of recent studies on CECs in various cardiovascular conditions.

Main Results:

  • Increased CEC numbers are observed in cardiovascular diseases like myocardial infarction, stroke, and diabetes.
  • CEC levels remain unchanged in conditions such as stable hypertension and atrial fibrillation.
  • CEC quantification post-myocardial infarction predicts major adverse coronary events and mortality.

Conclusions:

  • CEC quantification is a developing, reproducible method for assessing endothelial damage.
  • Elevated CECs are linked to cardiovascular disease and its risk factors.
  • CEC levels serve as a prognostic indicator for adverse cardiovascular events.