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Pulmonary function in multiple sclerosis without any respiratory complaints.

Ayse Altintas1, Tuncalp Demir, Hande Demirel Ikitimur

  • 1Istanbul University, Cerrahpasa Medical Faculty, Department of Neurology, Istanbul, Turkey.

Clinical Neurology and Neurosurgery
|October 19, 2006
PubMed
Summary
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Multiple sclerosis (MS) patients show early signs of respiratory muscle dysfunction, even without symptoms. Changes in forced vital capacity (FVC) between upright and supine positions can predict this decline in respiratory function.

Area of Science:

  • Neurology
  • Pulmonology
  • Respiratory Medicine

Background:

  • Pulmonary complications are common in severe multiple sclerosis (MS), often linked to respiratory muscle dysfunction.
  • The progression of respiratory muscle dysfunction and its correlation with disability in MS patients remain unclear.
  • Early detection of respiratory impairment is crucial for managing MS progression.

Purpose of the Study:

  • To investigate the predictive value of respiratory muscle functions in detecting early-stage respiratory deterioration in MS.
  • To assess the change in forced vital capacity (Delta FVC) as an indicator of respiratory muscle dysfunction in MS.
  • To explore the association between respiratory muscle function and disability in the early phase of MS.

Main Methods:

  • Twenty-one MS patients and seventeen healthy controls underwent pulmonary function tests (PFTs).

Related Experiment Videos

  • Tests included lung volumes, diffusion capacity (DLCO), respiratory muscle strength (P(Imax), P(Emax)), and respiratory center function (P(0.1)).
  • PFTs were conducted in both upright and supine positions to calculate Delta FVC.

    • Main Results:

    • MS patients exhibited significantly lower diffusion capacity, respiratory muscle strength, and P(0.1) compared to controls.
    • The difference in FVC between upright and supine positions (Delta FVC) was significantly higher in MS patients than in controls.
    • These findings suggest subclinical respiratory muscle dysfunction in MS patients.

    Conclusions:

    • Pulmonary dysfunction is present in MS patients, even in the absence of respiratory symptoms.
    • Delta FVC may serve as a valuable tool for detecting early respiratory muscle dysfunction in MS.
    • Further research is warranted to understand the long-term implications of these findings on MS disability.