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Updated: Jul 19, 2026

Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells
Published on: February 12, 2021
Coactivator control of cardiovascular growth and remodeling
1Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Blvd., Dallas, TX 75390, USA.
Abstract:
Transcriptional coactivators enhance gene expression by associating with sequence-specific transcription factors and serve as the primary targets of developmental and physiological signals in diverse biological processes. Recent studies have revealed key roles for transcriptional coactivators in the control of gene expression during development, growth and remodeling of the cardiovascular system. Based on the importance of the cardiovascular coactivators identified to date, coactivator control is emerging as a central regulatory mechanism in development and homeostasis of the cardiovascular system and other tissues.
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