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Updated: Jul 19, 2026

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Published on: February 27, 2026
Malignant non-Hodgkin's lymphoma developing late after pneumonectomy
Gregory Riehl1, Axel Aubert, Cristian Sandu
1Department of Thoracic and Vascular Surgery, A. Michallon Teaching Hospital, BP 217, 38043 Grenoble cedex 9, France. GRiehl@chu-grenoble.fr
Summary
A rare thoracic malignancy, malignant non-Hodgkin's lymphoma (MNHL), developed in a patient six years after treatment for benign bronchial stenosis. The patient achieved remission after chemotherapy and radiation therapy.
Area of Science:
- Thoracic oncology
- Hematologic malignancies
- Medical case reports
Background:
- A 64-year-old male underwent left pneumonectomy for benign bronchial stenosis in 1968.
- Long-term follow-up after thoracic surgery is crucial for detecting secondary conditions.
Observation:
- In 1997, a left parietal thoracic tumor was diagnosed as T-type malignant non-Hodgkin's lymphoma (MNHL).
- This rare presentation occurred 29 years post-pneumonectomy.
Findings:
- The MNHL was successfully treated with chemotherapy and radiation therapy.
- The patient remained alive and in remission six years after treatment.
- Only one prior case of MNHL in this specific location was found in the literature.
Implications:
- This case may represent a rare instance of pyothorax-associated lymphoma (PAL).
- Further research into PAL, particularly from non-Japanese literature, is warranted.
- Highlights the importance of vigilance for secondary malignancies after extensive thoracic procedures.
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