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Epidemiology and strain characterization of rotavirus diarrhea in Malaysia

L C Hung1, S L Wong, L G Chan

  • 1Institute of Paediatrics, Kuala Lumpur Hospital, 50586 Kuala Lumpur, Malaysia. lchung@hkl.gov.my

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
|October 19, 2006
PubMed

Insights

Rotavirus (RV) caused 38% of diarrhea hospitalizations in Malaysian children under five. The P[8]G9 strain was most common, with no observed seasonality in cases.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Public health surveillance

Background:

  • Rotavirus (RV) is a leading cause of severe diarrhea in young children globally.
  • Understanding the epidemiology and burden of RV is crucial for public health interventions.
  • Malaysia lacks comprehensive data on RV disease burden in hospitalized children.

Purpose of the Study:

  • To describe the epidemiology and strain characteristics of rotavirus (RV) in Malaysia.
  • To determine the proportion of diarrhea hospitalizations attributable to RV in children under five.
  • To estimate the disease burden of RV-associated diarrhea.

Main Methods:

  • Prospective surveillance of children aged 0-59 months admitted for acute gastroenteritis at two Malaysian hospitals (Kuala Lumpur Hospital and Hospital Umum Sarawak).
  • Data collection occurred between February 2001 and April 2003.
  • Rotavirus strains were characterized, and epidemiological data were analyzed.

Main Results:

  • Rotavirus accounted for 38% of all diarrhea hospitalizations.
  • The highest incidence was observed in children aged 6-17 months (55%).
  • The predominant RV strain was P[8]G9 (73% overall), with no significant seasonality detected.

Conclusions:

  • Rotavirus is a significant cause of childhood diarrhea hospitalizations in Malaysia, particularly in infants and toddlers.
  • The P[8]G9 strain is the dominant circulating genotype.
  • The estimated annual incidence of RV-associated diarrhea is 27 per 10,000 children under five.
Abstract

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