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Influence of hydrogen bonds on charge distribution and conformation of L-arginine
Liang Xian1, Shuhua Liu, Yanqing Ma
1State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China.
Abstract:
The molecular recognition of adenosine-5'-triphosphate (ATP) with L-arginine (Arg) through hydrogen bonding interactions has been found using 1H NMR, H-H NOESY, acidity titration and fluorescence spectra techniques. The interactions could influence charge distribution in Arg and induce Arg conformational variation. It is realized that Arg conformation change from a partly folded state to an extended state through the rotation of CC single bonds of Arg side chain during the molecular recognition process.
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