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Substance p-induced cutaneous and bronchial reactions in children with bronchial asthma
Insights
Substance P triggers allergic skin and airway reactions in children. Lidocaine effectively reduced these substance P-induced responses, as well as reactions to histamine and house dust, without side effects.
Area of Science:
- Immunology
- Pulmonology
- Dermatology
Background:
- Substance P is implicated in allergic inflammation.
- Its role in pediatric allergic disorders requires further investigation.
Purpose of the Study:
- To investigate substance P-induced cutaneous and bronchial reactions in children with allergic disorders.
- To evaluate the inhibitory effects of lidocaine on these substance P-elicited responses.
Main Methods:
- Intradermal testing and bronchial challenge with substance P in children.
- Assessment of skin reactions (erythema, wheal) and lung function (FEV1, V50).
- Evaluation of lidocaine's effect on substance P, histamine, and house dust-induced reactions.
Main Results:
- Children with moderate/severe asthma showed heightened substance P reactions.
- Asthma severity correlated with increased airflow limitation following substance P challenge.
- Lidocaine significantly inhibited substance P, histamine, and house dust-induced reactions.
- No adverse events were reported with lidocaine administration.
Conclusions:
- Substance P plays a significant role in human cutaneous and bronchial hypersensitivity.
- Lidocaine demonstrates efficacy in inhibiting substance P-mediated allergic reactions.
Abstract:
We studied substance P-induced cutaneous and bronchial reactions in children with allergic disorders. Furthermore, inhibitory effects of lidocaine on these responses elicited by substance P were also studied. In the intradermal test, children with moderate or severe bronchial asthma showed significantly stronger reactions than controls. In bronchial challenge with substance P, children with bronchial asthma showed an increasing fall in FEV1 and V50 in proportion to the severity of their asthma. Concomitant use of lidocaine significantly inhibited not only substance P-induced intradermal erythema and wheal reactions but air flow limitations. It also inhibited histamine-induced erythema and house dust-induced wheal and erythema reactions. No adverse reactions to lidocaine were observed. These results suggest that substance P might play an important role in cutaneous and bronchial hypersensitivity reactions in humans and that lidocaine has an inhibitory effect on substance P-induced reactions.