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An X-ray microprobe facility using synchrotron radiation.

B M Gordon¹, K W Jones, A L Hanson

¹Department of Applied Science, Brookhaven National Laboratory, Upton, NY 11973.

Biological Trace Element Research

|July 1, 1990

Summary

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A new X-ray microprobe using synchrotron radiation (SR) offers trace elemental analysis at micrometer resolution. This advanced technique achieves high sensitivity in biological samples, enabling detailed biomedical studies.

Area of Science:

Analytical Chemistry
Biomedical Engineering
Physics

Background:

Development of advanced analytical techniques is crucial for trace elemental analysis.
Synchrotron radiation (SR) offers unique properties for high-resolution elemental mapping.
Existing methods may lack the spatial resolution or sensitivity required for certain biological samples.

Purpose of the Study:

To develop and characterize an X-ray microprobe for trace elemental analysis at micrometer spatial resolutions.
To evaluate the sensitivity and capabilities of the microprobe for biological samples.
To demonstrate the application of the developed microprobe in a biomedical study.

Main Methods:

Utilizing synchrotron radiation (SR) for X-ray excitation.

Related Experiment Videos

Employing two beamlines with different focusing optics (1:1 mirror and 8:1 ellipsoidal mirror).

Excitation using "white light" to induce characteristic X-ray fluorescence lines.

Main Results:

Achieved sensitivities in the range of 2-20 fg in 100 square micrometer areas within 5-minute irradiation times for thin biological samples.
Demonstrated capabilities for scanning techniques, microtomography, and chemical speciation.
Successfully applied the microprobe to a specific biomedical study.

Conclusions:

The developed X-ray microprobe provides high spatial resolution and sensitivity for trace elemental analysis in biological samples.
The facility, with its distinct beamlines and optics, is well-suited for advanced elemental mapping.
The technique shows significant potential for detailed investigations in biomedical research.