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Updated: Jul 19, 2026

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Assay for Phosphorylation and Microtubule Binding Along with Localization of Tau Protein in Colorectal Cancer Cells

Published on: October 10, 2017

Tau phosphorylation, aggregation, and cell toxicity.

J Avila¹, I Santa-María, M Pérez

¹Centro de Biología Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autónoma de Madrid, Campus de Cantoblanco, 28049 Madrid, Spain.

Journal of Biomedicine & Biotechnology

|October 19, 2006

Summary

This review discusses the controversy surrounding protein aggregate toxicity in neurodegenerative diseases, focusing on tau aggregation in tauopathies.

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Area of Science:

Neuroscience
Pathology

Background:

Protein aggregation is a hallmark of neurodegenerative disorders.
The role of these aggregates in disease pathogenesis is debated.
Tau aggregation is central to tauopathies.

Purpose of the Study:

To review the controversy regarding the toxicity of protein aggregates.
To specifically examine the role of tau aggregation in tauopathies.

Main Methods:

Literature review and synthesis of existing research.
Discussion of conflicting findings and interpretations.

Main Results:

Evidence for and against the direct toxicity of protein aggregates is presented.
The specific mechanisms of tau aggregate toxicity are explored.

Conclusions:

The precise contribution of protein aggregates to neurodegeneration remains controversial.
Further research is needed to clarify the toxic roles of specific aggregate species in tauopathies.