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Related Experiment Video

Updated: Jul 19, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

Parietal cortex activation predicts memory decline in apolipoprotein E-epsilon4 carriers.

Johanna Lind¹, Martin Ingvar, Jonas Persson

¹Department of Clinical Neuroscience, Karolinska Institute, MR Research Center, Karolinska Hospital, and Department of Psychology, Stockholm University, Stockholm, Sweden. Johanna.lind@ki.se

|October 19, 2006

Summary

Apolipoprotein E-epsilon4 carriers at risk for Alzheimer's disease showed parietal cortex changes that predicted future memory decline. This finding suggests parietal function may indicate Alzheimer's progression in at-risk individuals.

Related Experiment Videos

Last Updated: Jul 19, 2026

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

Area of Science:

Neuroscience
Genetics
Medical Imaging

Background:

Apolipoprotein E-epsilon4 (APOE4) is the primary genetic risk factor for Alzheimer's disease (AD).
Functional abnormalities in the parietal cortex are observed in AD patients and individuals at genetic risk.
The predictive value of parietal cortex integrity for AD progression in at-risk individuals remains critical to ascertain.

Purpose of the Study:

To investigate if parietal cortex integrity, measured via functional MRI, can predict cognitive decline.
To assess the relationship between parietal cortex function and episodic memory performance in at-risk individuals.

Main Methods:

Studied nondemented individuals carrying the apolipoprotein E-epsilon4 allele.
Utilized blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) during a word categorization task.
Correlated fMRI response in the parietal cortex with subsequent episodic memory performance.

Main Results:

A significant relationship was found between parietal BOLD fMRI response and subsequent episodic memory performance.
Parietal cortex alterations were associated with memory decline in APOE4 carriers.

Conclusions:

Parietal cortex functional alterations predict memory decline in nondemented APOE4 carriers.
These findings suggest parietal cortex integrity is a potential biomarker for predicting Alzheimer's disease progression.