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Related Experiment Video

Updated: Jul 19, 2026

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
09:57

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Published on: January 2, 2012

Cortical sulci and bipolar disorder.

Thomas R Coyle1, Peter Kochunov, Rupal D Patel

  • 1Department of Psychology, University of Texas at San Antonio, Texas 78249, USA, and Service Hospitalier Frédéric Joliot, Commissariat à l'Energie Atomique, Orsay Cedex, France. Thomas.Coyle@utsa.edu

Neuroreport
|October 19, 2006
PubMed
Summary

Bipolar patients exhibit wider cortical sulci compared to healthy individuals, particularly in frontal regions. This finding suggests potential neurodegenerative processes contributing to brain structural differences in bipolar disorder.

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Last Updated: Jul 19, 2026

How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
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08:29

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

Area of Science:

  • Neuroimaging
  • Brain Anatomy
  • Psychiatric Disorders

Background:

  • Bipolar disorder is a complex mental health condition.
  • Structural brain abnormalities are increasingly recognized in bipolar disorder.
  • Cortical sulci width may reflect underlying neurobiological changes.

Purpose of the Study:

  • To investigate cortical sulcal width differences between bipolar patients and healthy controls.
  • To identify specific brain regions most affected by these differences.
  • To explore potential neurodegenerative underpinnings of observed structural changes.

Main Methods:

  • Utilized a novel automated magnetic resonance imaging (MRI) technique.
  • Quantified sulcal width across the entire cortex in both patient and control groups.
  • Compared sulcal width measurements between 19 bipolar patients and 35 healthy controls.

Main Results:

  • All examined sulci were significantly wider in bipolar patients than in healthy controls.
  • The largest bipolar-control differences in sulcal width were observed in the superior and intermediate frontal sulci.
  • Occipital and cingulate sulci showed the smallest differences, with other sulci (intraparietal, inferior frontal, central) showing intermediate differences.

Conclusions:

  • Wider cortical sulci in bipolar disorder suggest potential cortical atrophy.
  • These findings support the hypothesis of neurodegenerative-illness-related processes in bipolar disorder.
  • Further research is warranted to elucidate the precise mechanisms linking sulcal widening to bipolar disorder pathophysiology.