[Immunological aspects of pathogenesis of stomatological constructional materials intolerance]

In blood and the mixed saliva of patients with intolerance of stomatologic constructional materials the maintenance of cytokines, factors of humoral answer were investigated. It was established, that in formation of intolerance the increased sensitivity stomatologic constructional materials which is not connected to allergic reaction of immediate type and is, apparently, pseudoallergic or develops on other type. There is an activation of the local immune answer including local synthesis of proinflammatory cytokines, sIgA and hyperactivation of complement system to formation of C3a component. Toxic and allergic action of stomatologic constructional materials grows in patients having antibodies to Candida albicans in the mixed saliva.